Chemikalien und Kontaktallergie
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Detailed Information: Chemikalien und Kontaktallergie (KA00)
Contact allergens is a fact database in German language and contains the evaluations of the contact allergenic effect of synthetically produced chemicals as well as chemically defined ingredients in connection with natural products. For the detection of contact allergenic attributes and for the evaluation of their corresponding effectiveness the findings of experiments done on animals, as well as clinical experiences, have been used. This database is not updated anymore and is offered as an archive file.
Content navigation
- Database Content: Subject Coverage | Type | Language | Sources | Superbases
- Database Resources: File Size | File Data | Update Cycle
- Query: Special Notes | Vocabulary | Searchable Data Fields | Data Fields, alphabetical | Data Fields, systematical | Output of Search Results | Sample Search(es) | Sample Record(s)
- Contact: Producer | Contact Person
Database Content
| Subject Coverage | Toxicology/Medicine |
|---|---|
| Type | Fact database |
| Language | German |
| Sources | Research group Allergenliste of the BfR with experts from universities as well as medical specialists, representatives from the chemical industry and from Superior Federal Agencies of Science. |
| Superbases | There are predefined databases groups (superbase) for several subjects. The database Chemikalien und Kontaktallergie is part of the following superbases: |
Database Resources
| File Size | 244 (Status 03/2005) |
|---|---|
| File Data |
You will find the number of database records in the current update status. |
| Update Cycle | Not updated |
Query
Special Notes
On the evaluated compilation of chemicals with contact allergen characteristics, great distinctions emerge between the individual substances and groups of substances both in the sensitizing concentration efficacy and the frequency of occurrences of the allergic reactions caused by them. In order to obtain homogeneous groups of substances with comparable concentration efficacy and significance, the substances were divided into 3 different categories that are searchable in the database:
- Category A: significant contact allergen
- Category B: justified evidence of contact allergen impact
- Category C: insignificant contact allergen or doubtful contact allergen impact
Standing orders (SDI) are not possible as this database is an archive file. It is not being updated or not being updated regularly.
Vocabulary
Chemical Terminology (NAME; SY; TE)
CAS-Numbers (CR) (Chemical Abstracts Service Registry Numbers)
Language of vocabulary: German
Searchable Data Fields
The following document sections are considered with the free text search (FT):
Kategorie (GRC)
Erfahrungen am Menschen (HTOX)
Substanz (NAME)
Bemerkungen (NOTE)
Tierexperimentelle Ergebnisse
(NTOX)
Synonyme (SY)
Schlussfolgerungen (TXHR)
Vorkommen (USE)
Search language(s) in the basic index:
German
Data Fields, alphabetical
Explanation:
D = DISPLAY F = FIND S = SHOW
1 : front-end-masking recommended
2 : searchable word by word with field label
3 : searchable only selectively
(F): field is searchable
only via basic index
| Command | Field Name | Examples | Comments |
|---|---|---|---|
| D F S | CR CAS- Nummer (CAS-Number) | F CR= 99-76-3 | |
| S | DAT Datenpflegeangaben (Datamaintenance) | ||
| D F S | GRC Kategorie (Category) | F GRC= bedeutendes kontaktallergen | |
| D F S | GRCC Kategoriecode (Category Code) | D GRCC=?
F GRCC= a |
Code pertaining to GRC. |
| (F) S | HTOX Erfahrungen am Menschen (Experiences on humans) | F ekzem?/HTOX | |
| (F) S | IDEN Identifizierung (Identification) | F mansonon/IDEN | Field Group. Arrangement of fields: see hierarchical table. |
| S | LINK Originaldokument (Original document) | Original document in WORD-format | |
| D F S | MF Summenformel (Totals formula) | F MF= c21h36o2 | |
| D F S | NAME Substanz (Substance) | F NAME= urushiol | The field name and synonym can be searched for together via the TE field. |
| D F S | ND Dokumentnummer (Document number) | F ND= ka147 | |
| (F) S | NOTE Bemerkungen (Remarks) | F kreuzreaktivität/NOTE | Additional information e.g. cross reference. |
| (F) S | NTOX Tierexperimentelle Ergebnisse (Results of animal experiments) | F draize-test/NTOX | |
| S | OSID Weitere Substanzidentifizierung (Further identification of substance) | ||
| D F² S | RF Literatur (Literature) | F parker/RF | |
| D F S | RL Dokumentenlänge (Document length) | RL:3664 | |
| S | SNUM Substanzidentifizierungsnummern (Identification number of substance) | ||
| S | SSTRU Substanzstruktur (Substance structure) | Graphic display of substance structure can only be accessed as word document. | |
| S | STRUCD Strukturformel (Chemical structure) | ||
| D F S | SY Synonyme (Synonyms) | F 2-Propenoic acid, 2-hydroxypropyl ester/SY | The field name and synonym can be searched for together via the TE field. |
| D F S | TE Chemische. Terminologie (Chemical terminology) | F TE= urushiol | Extends across NAME; SY. |
| (F) S | TOXI Toxizität/ Wirkungen (Toxicity/ Effects) | F kontaktdermatiden/TOXI | Field Group. Arrangement of fields: see hierarchical table. |
| (F) S | TXHR Schlussfolgerungen (Conclusions) | F hautirritation/TXHR | |
| (F) S | USE Vorkommen (Source) | F essigbaum/USE |
Data Fields, systematical
Arrangement in the documentary unit
Explanation:
D = DISPLAY F = FIND S = SHOW
1 : front-end-masking recommended
2 : searchable word by word with field label
3 : searchable only selectively
(F): field is searchable
only via basic index
| Field Name | Command |
|---|---|
| ++ DAT Datenpflegeangaben (Datamaintenance) | S |
| ND Dokumentennummer (Document number) | D F S |
| RL Dokumentenlänge (Document length) | D F S |
| ++ IDEN Identifizierung (Identification) | (F) S |
| + TE Chemische Terminologie (Chemical terminoloby) | D F S |
| NAME Substanz (Substance) | D F S |
| SY Synonyme (Synonyms) | D F S |
| + SNUM Substanzidentifizierungsnummern (Identification number of substance) | S |
| CR CAS Nummer (CAS Number) | D F S |
| + SSTRU Substanzstruktur (Substance structure) | S |
| MF Summenformel (Totals formula) | D F S |
| STRUCD Strukturformel (Chemical structure) | S |
| + OSID Weitere Substanzidentifizierung (Further identification of substance) | S |
| GRCC Kategoriecode (Category code) | D F S |
| GRC Kategorie (Category) | D F S |
| ++ USE Vorkommen (Source) | (F) S |
| ++ TOXI Toxizität / Wirkungen (Toxicity / Effects) | (F) S |
| HTOX Erfahrungen am Menschen (Experiences on humans) | (F) S |
| NTOX Tierexperimentelle Ergebnisse (Results of animal experiments) | (F) S |
| THXR Schlussfolgerungen (Conclusions) | (F) S |
| ++ NOTE Bemerkungen (Remarks) | (F) S |
| ++ RF Literatur (Literature) | D F² S |
| ++ Link Originaldokument (Original document) | S |
Output of Search Results
By means of the commands: SHOW (S) / MAIL.
Corresponding to the copyright rules use the parameter USE=DLOAD if necessary. You may ask for all data fields, single data fields, or sets of data fields. If the output fields are not specified explicitly, the standard field set (F=STD) is used in all output commands.
Output field sets:
| Command | Field Set | Associated Datafields |
|---|---|---|
| F=STD | Standard | same as F= ALL |
| F=ALL | all fields | ND, RL, NAME, SY, CR, MF, STRUCD, GRCC, GRC, USE, HTOX, NTOX, TXHR, NOTE, RF, LINK |
Sample Search(es)
Database selection in DIMDI ClassicSearch: SBAS KA00
1. Substance Search: You can carry out a substance search with the help of a descriptor-identifier TE (searches directly in the fields name and synonym) or with the CAS Registry Number (CR):
Profil table:
| Parameter | Counter | Number of Hits | Query |
|---|---|---|---|
| C= | 1 | 244 | KA00 |
| S= | 2 | 1 | TE=CARABRON |
| 3 | 1 | CR=1748-81-8 |
2. Thematic Search: We are searching for herbal ingredients that have a powerful contact allergen effect and that cause eczema in humans.
Profil table:
| Parameter | Counter | Number of Hits | Query |
|---|---|---|---|
| C= | 1 | 244 | KA00 |
| S= | 2 | 9 | PFLANZE# OR PFLANZLICH? OR ? BAUM OR KRA#UT |
| 3 | 49 | EKZEM?/HTOX | |
| 4 | 84 | HAUT?/HTOX | |
| 5 | 118 | 3 OR 4 | |
| 6 | 100 | GRCC=A | |
| 7 | 3 | 2 AND 5 AND 6 |
Sample Record(s)
2/1 of 1 DIMDI: Chemikalien und Kontaktallergie (KA00) © BfR
| ++ DAT Datenpflegeangaben | |
| ND Dokumentnummer: | KA127 |
| MD Maschinendatum: | 14.01.2003 |
| RL Dokumentlaenge: | 3664 |
| ++ IDEN Identifizierung | |
| + TE Terminologie, chemische | |
| NAME Substanz: | (R)-3,4-Dimethoxydalbergion |
| SY Synonyme: |
(R)-2,3-Dimethoxy-5-(1-phenyl-2-propenyl)-2,5-cyclohexadiene-1,4-dione;
(R)-2,3-Dimethoxy-5-(1-phenylallyl)-p-benzochinon |
| + SNUM Substanzidentifizierungsnummern | |
| CR CAS-Nummer: | 3755-64-4 |
| + SSTRU Substanzstruktur | |
| MF Summenformel: | C17H16O4 |
| STRUCD Strukturformel: | B_3755-64-4.doc |
| + OSID Weitere Substanzidentifizierung | |
| GRCC Kategoriecode: | A |
| GRC Kategorie: | Bedeutendes Kontaktallergen |
| ++ USE Vorkommen | |
| (R)-3,4-Dimethoxydalbergion ist ein Naturstoff und kommt als Chinon oder in Form seiner phenolischen Vorstufe in Konzentrationen von 0,5 % bis 3,5 % im Holz von Machaerium-Arten, insbesondere in Machaerium scleroxylon Tul. vor [8]. Das auch als Pao ferro, Caviuna vermelha, Moradillo, Santos-Palisander bezeichnete Holz stammt aus Südamerika (Brasilien) und wurde auch als Ersatz für Rio-Palisander (Dalbergia nigra) angeboten. | |
| ++ TOXI Toxizitaet/Wirkungen | |
| HTOX Erfahrungen
am Menschen: |
Bei der Verarbeitung des Holzes zu Möbeln, Furnieren, Blasinstrumenten u.a. wurden Fälle von akuten Kontaktdermatiden bei den Exponierten in gehäuftem Umfange beobachtet, die auf die Einwirkung des feinen Holzstaubes zurückzuführen waren [1,2,3,5,6,8]. In einer Übersichtsarbeit wird über 140 Krankheitsfälle berichtet [4]. Als auslösendes Agens wurde das stark sensibilisierende R-3,4-Dimethoxydalbergion erkannt [8]. Noch in geringen Konzentrationen von 0,1 % und darunter wurden positive Epikutan-Teste erhalten. Das hohe Sensibilisierungspotential, welches das von anderen Dalbergionen deutlich übertrifft, geht auch daraus hervor, dass eine einmalige, in Form eines üblichen Epikutan-Testes vorgenommene Applikation mit Machaerium-Holzstaub Sensibilisierungen induziert hat [7]. |
| NTOX Tierexperiment.
Ergebnisse: |
An Meerschweinchen wurde mit Hilfe einer relativ unempfindlichen Methode (zweimalige subkutane Injektion einer 1/100 molaren Lösung mit FCA im Abstand von 4 Tagen) das hohe Sensibilisierungspotential bestätigt. Bei der Auslösebehandlung reagierten noch 11 von 12 Tieren auf eine 1/500 molare Lösung (etwa 0,06 %), auf eine 1/1000 molare Lösung ( ca. 0,03 %) noch 10 von 12 Tieren schwach bis deutlich positiv [9]. |
| TXHR Schluss-
folgerung: |
(R)-3,4-Dimethoxydalbergion wirkt sowohl beim Menschen als auch beim Tier stark sensibilisierend. Es besitzt das stärkste Sensibilisierungsvermögen aller Dalbergione. Es gehört nach Primin (Becherprimel) und Desoxylapachol (Teakholz) zu den stärksten, natürlich vorkommenden Allergenen von Chinon-Struktur [9]. |
| ++ RF Literatur | |
| [1]Beck, M.H.; Hausen, B.M.; Dave, V.K.: Allergic contact
dermatitis from Machaerium scleroxylon Tul. in a joinery shop.
Clin. Exp. Dermatol. 9, 159-166 (1984);
[2]Chieregata, C.; Vincenzi, C.; Guerra, L.; Rapacchiale, S.: Occupational airborne contact dermatitis from Machaerium scleroxylon. Contact Dermatitis 29, 164-165 (1993); [3]Conde-Salazar, L.; Garcia-Diez, A.; Rafeensberger, F.: Contact allergy to the Brazilian rosewood substitute Machaerium scleroxylon Tul. (Pao ferro). Contact Dermatitis 6, 246-250 (1980); [4]Hausen, B.M.: Häufigkeit und Bedeutung toxischer und allergischer Kontaktdermatiden durch Machaerium scleroxylon Tul., einem Ersatzholz für Palisander (Dalbergia nigra All.). Hautarzt 33, 321-328 (1982); [5]Hjorth, N.: Occupational dermatitis from Pao ferro. Contact Dermatitis Newsletter 16, 473 (1974); [6]Holst, R.; Kirby, J.; Magnusson, B.: Sensitization to tropical woods giving erythema multiforme-like eruptions. Contact Dermatitis 2, 295-296; [7]Maibach, H.J.: Active sensitization to wood extracts. Contact Dermatitis Newsletter 7, 149 (1970); [8]Morgan, J.W.W.; Orsler, R.J.; Wilkinson, D.S.: Dermatitis due to the wood dusts of Khaya anthotheca and Machaerium scleroxylon. Br. J. Ind. Med. 25, 119-125 (1969); [9]Schulz, K.H.; Garbe, I.; Hausen, B.M.; et al.: The sensitizing capacity of naturally occuring quinones. Benzoquinones. Arch. Dermatol. Res. 264, 275-286 (1979) |
|
| ++ LINK Originaldokument | |
| 3755-64-4.doc | |
Output-Format: SHOW F=STD
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