BIOSIS PREVIEWS

The field CT contains up to 13 special parts. These are 11 of the 12 main branches of the BIOSIS-Authority File, and the MeSH Headings and Gene Names:

MAJOR CONCEPTS: hierarchical
SUPER TAXA (Biosystematic Codes): hierarchical
ORGANISMS: flat
TAXA NOTES: flat
PARTS, STRUCTURES, AND SYSTEMS (of Organisms): flat
METHODS AND EQUIPMENT: hierarchical
DISEASES: flat
MESH HEADING (in approx. 10 % of the documents): flat
CHEMICALS AND BIOCHEMICALS: flat
GENE NAME: flat
SEQUENCE DATA: flat
GEOPOLITICAL LOCATIONS: hierarchical
GEOLOGIC TIME: hierarchical

The 12th main branch, the concept codes, is searchable with the CT field and the SH field, e.g.

D  CT   DOWN  concept codes
F  CT = phytopathology?
F  CT = 54502

In the (SHOW) display they are only visible in the SC field. In the (SHOW F= DES) display there are visible in the SH field.

These main branches of the BIOSIS-Authority File are searchable like a descriptor, e.g.: FIND CT=SEQUENCE DATA (seeks for all documents with the special part SEQUENCE DATA).
It is possible to limit the search to a special part of the CT field,
e.g.: FIND CT=primates/ORG

It is possible to search for terms being not only together in one part of the CT field but also closely connected,
e.g.: FIND CT=(primates AND fetus)/SAME CONT

Each main branch represents a list or lists of descriptors (Controlled Terms). In part they have a hierarchical structure, i.e. with DISPLAY CT DOWN … you are able to display sub-terms. Additional information is available for each of the approx. 1,300 Controlled Terms from these lists (see under "vocabulary").

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Controlled Terms (CT) (Controlled descriptors from the "BIOSIS-Authority File")
Language: English

For several CTs the following additional information is available:

Concept Codes (SC), Concept Headings (SH) (Controlled descriptors for broad subject areas)
Language: English

Biosystematic Codes (BC), Biosystematic Headings (BS) (Controlled descriptors for higher taxonomic categories of indexed organisms)
Language: English

Uncontrolled Terms (UT) (Uncontrolled and semi-controlled descriptors)
Language: English

Database selection in DIMDI ClassicSearch: SBAS BA26; SBAS BA70; SBAS BA83; SBAS BA90; SBAS BA95; SBAS BA00; SBAS BA05; SBAS BA10; SBAS BIOSIS Previews

Subject: Genetic studies on the mycotic resistance of the rice plant

This subject covers four concepts: a) rice plant, b) genetic studies, c) fungal contamination, d) resistance.

First a search with the fields CT and SH is shown.

The first concept can be searched via free text in TI and UT. Both scientific and common names are included in the search profile. The other three concepts are searchable via Concept Headings (SH). To find suitable Concept Headings, the DISPLAY command can be used (e.g. DISPLAY SH=phytopathology?) But of course the CT field can be used for the search.

Profile table 1:

Another possibility is searching only with use of the CT-field. The search can be limited to certain „sub-fields", main branches of the BIOSIS-Authority File, by qualification. For this purpose the first 2 letters (with ORGANISMS the first 3 letters) can be used as qualifier.
If the CT field is not sufficient with some questions (in our example "resistance") the UT field can be included in the search. Since the concept codes were assigned to the CT field as synonyms, they are searchable as CT.

Profile table 2:

2/1 of 1 DIMDI: BIOSIS Previews (BA70) © Thomson Reuters

ND:	BAPREV200700345295
LR:	20070713
AU:	Ying SW; Goldstein PA
TI:	Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels
SO:	Molecular Pain; VOL: 1 /JAN 14 2005/; www.molecularpain.com/
ANR:	2
DOI:	10.1186/1744-8069-1-2
LA:	English
ISSN:	1744-8069
EISSN:	1744-8069(electronic)
CS:	Goldstein, Peter A.,Cornell Univ, CV Starr Lab Mol Neuropharmacol, Dept Anesthesiol, Weill Med Coll, 1300 York Ave,Room A-1050, New York, NY 10021 USA, svy2OO1@med.cornell.edu, pag2O14@med.cornell.edu
COU:	USA
DT:	Article
SC:	CONCEPT CODES; 02506 ... Cytology - Animal; 02508 ... Cytology - Human; 10060 ... Biochemistry studies - General; 10064 ... Biochemistry studies - Proteins, peptides and amino acids; 10508 ... Biophysics - Membrane phenomena; 12512 ... Pathology - Therapy; 20504 ... Nervous system - Physiology and biochemistry; 22005 ... Pharmacology - Clinical pharmacology; 22024 ... Pharmacology - Neuropharmacology
CT:	MAJOR CONCEPTS; Anesthesiology (Medical Sciences); Nervous System (Neural Coordination); SUPER TAXA; Hominidae: Primates, Mammalia, Vertebrata, Chordata, Animalia; Muridae: Rodentia, Mammalia, Vertebrata, Chordata, Animalia; ORGANISMS; human (common) (Hominidae); mouse (common) (Muridae); TAXA NOTES; Animals; Chordates; Humans; Mammals; Primates; Vertebrates; Nonhuman Vertebrates; Nonhuman Mammals; Rodents; PARTS, STRUCTURES, AND SYSTEMS; neuron: nervous system; brain: nervous system; thalamus: nervous system; reticular thalamic nucleus: nervous system; ventrobasal complex: nervous system; corticothalamic fiber: nervous system; METHODS AND EQUIPMENT; voltage-clamp recording: laboratory techniques, histology and cytology techniques; CHEMICALS AND BIOCHEMICALS; glutamate receptors; propofol: general anesthetic-drug, intravenous administration, dosage; gamma-aminobutyric acid-A receptors [GABA-A receptors]
TE:	propofol/2078-54-8
CR:	2078-54-8
BC:	86215 ... Hominidae; 86375 ... Muridae
AB:	Propofol is a widely used intravenous general anesthetic. Propofol-induced unconsciousness in humans is associated with inhibition of thalamic activity evoked by somatosensory stimuli. However, the cellular mechanisms underlying the effects of propofol in thalamic circuits are largely unknown. We investigated the influence of propofol on synaptic responsiveness of thalamocortical relay neurons in the ventrobasal complex (VB) to excitatory input in mouse brain slices, using both current- and voltage-clamp recording techniques. Excitatory responses including EPSP temporal summation and action potential firing were evoked in VB neurons by electrical stimulation of corticothalamic fibers or pharmacological activation of glutamate receptors. Propofol (0.6 - 3 mu M) suppressed temporal summation and spike firing in a concentration-dependent manner. The thalamocortical suppression was accompanied by a marked decrease in both EPSP amplitude and input resistance, indicating that a shunting mechanism was involved. The propofol-mediated thalamocortical suppression could be blocked by a GABA(A) receptor antagonist or chloride channel blocker, suggesting that postsynaptic GABA(A) receptors in VB neurons were involved in the shunting inhibition. GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs) were evoked in VB neurons by electrical stimulation of the reticular thalamic nucleus. Propofol markedly increased amplitude, decay time, and charge transfer of GABA(A) IPSCs. The results demonstrated that shunting inhibition of thalamic somatosensory relay neurons by propofol at clinically relevant concentrations is primarily mediated through the potentiation of the GABA(A) receptor chloride channel-mediated conductance, and such inhibition may contribute to the impaired thalamic responses to sensory stimuli seen during propofol-induced anesthesia.
full text
*** End of SHOW ***

Output format: SHOW F=ALL

List of the PreProcessed Searches

For the following subjects preprocessed searches are available:

AIDS
ANIMAL
CANCER
HUMAN
MEETINGS
TOXICOLOGY