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Gesamtinformationen: RTECS (RT00)
RTECS (Registry of Toxic Effects of Chemical Substances) enthält Informationen zu potenziell für die Umwelt gefährlichen Substanzen. Quellen sind ca. 1.000 Zeitschriften, Bücher, Konferenzbeiträge und private Mitteilungen an accelrys. Nachgewiesen werden CAS-Nummern, Vorzugsbezeichnungen, Synonyme, Strukturinformationen, Karzinogenitätsstudien, Mutagenitätsstudien, allgemeine Toxizitätsstudien, Studien zu Fortpflanzung, Haut oder Augenirritationen, Übersichtsartikel über Toxikologie und Karzinogenese, Grenzschwellenwerte sowie gesetzliche Regelungen für chemische Substanzen in den USA.
RTECS® is a United States trademark owned and licensed under authority of the U.S. Government, by and through accelrys.
Inhaltsübersicht (Navigation innerhalb der Gesamtinformationen)
- Datenbank-Inhalt: Sachgebiete | Datenbanktyp | Sprache | Quellen | Datenbankgruppen
- Datenbank-Bestand: Umfang | Datenbestand | Aktualisierungsintervall
- Recherche: Hinweise | Vokabular | Suchbare Textfelder | Datenfelder, alphabetisch | Datenfelder, systematisch | Ausgabe der Suchergebnisse | Suchbeispiel(e) | Beispieldokument(e)
- Kontakt: Hersteller | Ansprechpartner
- Anhang: Anhang
Datenbank-Inhalt
| Sachgebiete | Toxikologie Toxizitätsangaben: Daten zur Teratogenität, Mutagenität und Cancerogenität; gesetzliche Regelungen und Grenzschwellenwerte in den USA. |
|---|---|
| Datenbanktyp | Faktendatenbank |
| Sprache | Englisch |
| Quellen |
|
| Datenbankgruppen | Für einige Fachgebiete gibt es vordefinierte Datenbankgruppen. Die Datenbank RTECS ist in folgenden Datenbankgruppen enthalten: |
Datenbank-Bestand
| Umfang | 174.904 (Stand 06/2012) |
|---|---|
| Datenbestand |
Den tagesaktuellen Datenbankumfang finden Sie im Update-Status. |
| Aktualisierungsintervall | Vierteljährlich |
Recherche
Hinweise
Die Dokumentationseinheiten in RTECS können bei gut untersuchten Chemikalien sehr umfangreich sein (z.B. Studien), da sie zahlreiche Datenfelder enthalten können und viele Feldgruppen mehrfach ausgeprägt sein können.
Die Felder sind nach fachlichen Gesichtspunkten gruppiert. Die Gruppenbezeichnungen der Felder sind in der systematischen Anordnung durch ++ gekennzeichnet, Untergruppen werden mit einem + markiert. Gruppen und Untergruppen sind für die qualifizierte Suche verwendbar und können selektiv im SHOW angezeigt werden:
F (Suspected human carcinogen)/TOXR
S F=TOXR
Wegen des häufig sehr großen Datenumfangs eines Dokuments wird im Standard- SHOW neben den Feldern der Gruppen DATAMAINTENANCE und IDENTIFICATION OF SUBSTANCE lediglich ein Überblick über alle Felder eines Dokuments (nur Feldbezeichnungen, keine Daten) gegeben, in denen Daten enthalten sind. Die gesamten Dateninhalte sind mit SHOW F= ALL bzw. je nach Copyrightbestimmung mit SHOW F=ALL;USE=DLOAD abrufbar.
Durch die Ergänzung der Suchstichworte mit dem Zusatz /SAME CONT in der Suchabfrage werden nur die Studien gefunden, die alle Suchbegriffe im KONTEXT enthalten, d. h. es werden nur die Studien gefunden, in denen alle gesuchten Begriffe im Sinnzusammenhang zueinander stehen. Siehe auch Suchbeispiel 2.
Daueraufträge (SDI) sind nicht möglich, da mit jedem Update der gesamte Datenbestand neu geladen wird.
Vokabular
Chemical Names (NAME, TE)
CAS- Number (CR)
Beilstein Registry Number (BRN)
Sprache des Vokabulars: Englisch
Suchbare Textfelder
Folgende Dokumentabschnitte werden bei der Freitextsuche (FT) berücksichtigt:
Cancer Review (CREV)
Carcinogenicity Study (CSTU)
Cell Type (CTY)
Chemical Definition (CD)
Dose (DOS)
Effect (EFF)
Exposure Standards and
Regulations (EXSR)
General Toxicity Study (GSTU)
Group of Compound (GRC)
Indicator Organism (IOR)
Multiple Dose Study (MDSTU)
Mutagenicity Study (MSTU)
Name (Longterm) (N1L)
Name (NAME)
NIOSH Exposure Survey (NEXP)
NIOSH Recommendations (NREC)
Reproductive Study (RSTU)
Route (ROU)
Skin and Eye Irritation Study
(SSTU)
Species (SPE)
Standards and Regulations (SR)
Status of Tests (STA)
Study (STU)
Synonyms (SY)
Synonyms (Longterm) (SYL)
Test System (TSY)
Threshold Limit Value (TLV)
Toxicity/Biomedical Effects
(TOXI)
Toxicology and Carcinogenicity
Review (TOXR)
Toxicology Review (TREV)
Suchsprache(n) im Basic Index:
Englisch
Datenfelder, alphabetisch
Erläuterungen:
D = DISPLAY F = FIND S = SHOW
1 : Front-End-Maskierung wird empfohlen
2 : Wort für Wort mit Feldbezeichnung suchbar
3 : nur selektiv suchbar
(F): Feld ist
nur Freitext suchbar (siehe Basic Index)
| Kommando | Feldbezeichnung | Beispiele | Anmerkungen |
|---|---|---|---|
| D F S | BHR Beilstein Handbook Reference | F BHR=4-04-00-01081 | Gr- Nr.: 1.08 Format x-yy-zz-nnnnn; x=Nr. des Ergänzungswerks des Beilstein-Handbuch f. Org. Chemie (0=Hauptwerk); yy=Band- Nr.; zz=Teilband- Nr.; nnnnn=Seitenzahl |
| D F S | BRN Beilstein Registry Number | F BRN=773748 | Gr- Nr.: 1.07 |
| (F) S | CD Chemical Definition | F alkaloid/CD | Gr- Nr.: 1.15 |
| D F | CO Journal Code | F CO=pareaq | Internationaler Zeitschriftencode |
| D F S | CR CAS Number | F CR=75-07-0 | Gr- Nr.: 1.04 Schließt bei DISPLAY und FIND auch das Feld ON mit ein. |
| (F) S | CREV Cancer Review | F iarc/CREV | Gr- Nr.: 2.02 |
| (F) S | CSTU Carcinogenicity Study | F (tumorigenic AND mouse)/ CSTU | Gr- Nr.: 4.04.00 |
| D F | CTY Cell Type | F CTY= kidney F kidney/TOXI |
Wird ausgegeben im Feld SCR. Freitextsuche nicht mit /CTY qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| S | DAT Datamaintenance | Gr- Nr.: 0.00 Feldgruppe. Siehe systematische Anordnung. |
|
| D F S | DOS Dose | F DOS="1 gm/kg" F "1 gm/kg"/TOXI |
Gr- Nr.: 4.04.05; 4.01.05; 4.03.04; 4.05.05; 4.06.04; 4.02.05 Freitextsuche nicht mit /DOS qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| D F S | DTYP Data Type | F DTYP=mstu F mstu/TOXI |
Gr- Nr.: 4.04.01; 4.01.01; 4.03.01; 4.05.01; 4.06.01; 4.02.01 Freitextsuche nicht mit /DTYP qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| D F S | EFF Effect | F EFF=tumorigenic F tumorigenic/TOXI F tumorigenic/CSTU |
Gr- Nr.: 4.04.06; 4.01.06; 4.03.05; 4.05.06; 4.06.05; 4.02.06 Freitextsuche nicht mit /EFF qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| (F) S | EXSR Exposure Standards and Regulation | F carcinogen/EXSR | Gr- Nr.: 3.00 Feldgruppe. Siehe systematische Anordnung |
| D F | FF Formula Fragments Molecular | F FF=(c2 AND o) | Gr- Nr.: 1.12 |
| D F S | GRC Group of Compound | F GRC=tumorigen | Gr- Nr.: 1.14 |
| D (F) S | GSTU General Toxicity Study | F (rat AND oral)/GSTU | Gr- Nr.: 4.01.00 |
| S | IDEN Identification of Substance | Gr- Nr.: 1.00 Feldgruppe. Siehe systematische Anordnung. |
|
| D F | IOR Indicator Organism | F IOR=leukocyte F leukocyte/TOXI |
Wird im Feld SCR ausgegeben. Freitextsuche nicht mit /IOR qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| D F | JT Journal Title | F JT=kodak company reports | |
| (F) S | MDSTU Multiple Dose Studies | F (oral AND chicken)/MDSTU | Gr- Nr.: 4.02.00 |
| D F S | MF Molecular Formula | F MF="(C10-H15-N-O2)X" | Gr- Nr.: 1.11 |
| D F | MG Milligram | F MG=40 F MG<5 |
Direkt invertierte standardisierte Messwerte aus dem Unterfeld DOS. |
| D F | MGKG Milligram per Kilogram | F MGKG=500 to 1000 F MGKG<10 |
Direkt invertierte standardisierte Messwerte aus dem Unterfeld DOS. |
| D F | MGM3 Milligram per Cubic Meter | F MGM3=1 to 10 F MGM3<500 |
Direkt invertierte standardisierte Messwerte aus dem Unterfeld DOS. |
| (F) S | MSTU Mutagenicity Study | F (chromosome AND hamster)/MSTU | Gr- Nr.: 4.03.00 |
| D F S | MW Molecular Weight | F MW=44.06 | Gr- Nr.: 1.13 Keine Maskierung in FIND-Kommando möglich. |
| D F S | NAME Name | F TE=acetaldehyde F acetaldehyde/NAME |
Gr- Nr.: 1.02 |
| (F) S | N1L Name (Longterm) | F thia/N1L | Gr- Nr.: 1.03 |
| D F S | ND Number of Document (NIOSH) | F ND=RTAA7716000 | Gr- Nr.: 0.01 |
| (F) S | NEXP NIOSH Exposure Survey | F industries/NEXP | Gr- Nr.: 2.05 |
| (F) S | NREC NIOSH Recommendations | F nitric/NREC | Empfehlungen des National Institute for Occupational Safety and Health |
| S | ON Other Registry Number | F CR=8022-04-6 ON: 8022-04-6 |
Gr- Nr.: 1.05 Wird bei Suche nach CR mit abgesucht. |
| D F | PPM Parts per Million | F PPM=735 F PPM<20 |
Direkt invertierte standardisierte Messwerte aus dem Unterfeld DOSE. |
| D F 2 S | RF Reference | F RF=toxicology ? 1986 | Gr- Nr.: 4.04.07; 4.01.07; 4.03.06; 4.05.07; 4.06.05; 4.02.07 |
| S | RL Record Length | RL: 19584 | Gr- Nr.: 0.03 |
| D F S | ROU Route | F ROU=inhalation F inhalation/TOXI F inhalation/GSTU |
Gr- Nr.: 4.04.02; 4.01.02; 4.05.02; 4.06.02; 4.02.02 Freitextsuche nicht mit /ROU qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| (F) S | RSTU Reproductive Study | F (paternal AND rat)/RSTU | Gr- Nr.: 4.05.00 |
| D F S | RTEC RTECS Number | F RTEC=ab1925000 | Gr- Nr.: 1.06 |
| S | SCR Species/Cell Type/Route | Gr- Nr.: 4.03.03 | |
| D F S | SPE Species | F SPE=rat F rat/TOXI F rat/GSTU |
Gr- Nr.: 4.04.03; 4.01.03; 4.05.03; 4.06.03;4.02.03 Freitextsuche nicht mit /SPE qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| (F) S | SR Standards and Regulations | F gases/SR | Gr- Nr.: 3.01 |
| (F) S | SSTU Skin and Eye Irritation Study | F (eye AND rabbit)/SSTU | Gr- Nr.: 4.06.00 |
| (F) S | STA Status of Tests | F epa genetox, ? positive/STA | Gr- Nr.: 3.02 |
| D F S | STU Study | F STU=ld50 F ld50/TOXI F ld50/GSTU |
Gr- Nr.: 4.04.04; 4.01.04; 4.05.04; 4.02.04 Freitextsuche nicht mit /STU qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| D F S | SY Synonyms | F TE=acetaldehyde F acetaldehyde/SY |
Gr- Nr.: 1.10 |
| D F S | TE Terminology | F TE=acetaldehyde | Gr- Nr.: 1.01 Erstreckt sich über NAME; SY; CR |
| (F) S | TLV Threshold Limit Value | F stel/TLV | Gr- Nr.: 2.03 |
| (F) S | TOXI Toxicity Data | F rat/TOXI | Gr- Nr.: 4.00 Feldgruppe. Siehe Datenfelder (syst.) |
| (F) S | TOXR Toxicology and Carcinogenicity Review | F toxicology/TOXR | Gr- Nr.: 2.00 Feldgruppe. Siehe systematische Anordnung. |
| (F) S | TREV Toxicology Review | F residue/TREV | Gr- Nr.: 2.01 |
| D F S | TSY Test System | F TSY=dna repair F dna repair/TOXI |
Gr- Nr.: 4.03.02 Freitextsuche nicht mit /TSY qualifizierbar, sondern mit den entsprechenden Gruppenbezeichnungen. |
| D F S | WL Wiswesser Line Notation | F WL=vh1 | Gr- Nr.: 1.09 Bei Vorkommen von "&", "*" in Anführungszeichen setzen; es können 2 Leerstellen innerhalb 1 WL vorkommen. |
Datenfelder, systematisch
Anordnung in der Dokumentationseinheit
Erläuterungen:
D = DISPLAY F = FIND S = SHOW
1 : Front-End-Maskierung wird empfohlen
2 : Wort für Wort mit Feldbezeichnung suchbar
3 : nur selektiv suchbar
(F): Feld ist
nur Freitext suchbar (siehe Basic Index)
| Gruppen- Nr. | Feldbezeichnung | Kommando |
|---|---|---|
| 0.00 | ++ DAT Datamaintenance | S |
| 0.01 | ND Number of Document (NIOSH) | D F S |
| 0.02 | LR Last Revision Date | D F S |
| 0.03 | RL Record Length | S |
| 1.00 | ++ IDEN Identification of Substance | S |
| 1.02 | NAME Name | D F S |
| 1.03 | N1L Name (Longterm) | (F) S |
| 1.04 | CR CAS Number | D F S |
| 1.05 | ON Other Registry Number | S |
| 1.06 | RTEC RTECS Number | D F S |
| 1.07 | BNR Beistein Registry Number | D F S |
| 1.08 | BHR Beilstein Handbook Reference | D F S |
| 1.09 | WL Wiswesser Line Notation | D F S |
| 1.10 | SY Synonyms | D F S |
| 1.11 | MF Molecular Formula | (F) S |
| 1.12 | SYL Synonyms Longterm | D F S |
| 1.13 | MW Molecular Weight | D F S |
| 1.14 | GRC Group of Compound | D F S |
| 1.15 | CD Chemical Definition | (F) S |
| 2.00 | ++ TOXR Toxicology and Carcinogenicity Review | (F) S |
| 2.01 | TREV Toxicology Review | (F) S |
| 2.02 | CREV Cancer Review | (F) S |
| 2.03 | TLV Threshold Limit Value | (F) S |
| 2.04 | NREC NIOSH Recommendations | (F) S |
| 2.05 | NEXP NIOSH Exposure Survey | (F) S |
| 3.00 | ++ EXSR Exposure Standards and Regulation | (F) S |
| 3.01 | SR Standards and Regulations | (F) S |
| 3.02 | STA Status of Tests | (F) S |
| 4.00 | ++ TOXI Toxicity Data | (F) S |
| 4.01.00 | + GSTU General Toxicity Study | D (F) S |
| 4.01.01 | DTYP Data Type | D F S |
| 4.01.02 | ROU Route | D F S |
| 4.01.03 | SPE Species | D F S |
| 4.01.04 | STU Study | D F S |
| 4.01.05 | DOS Dose | D F S |
| 4.01.06 | EFF Effect | D F S |
| 4.01.07 | RF Reference | D F 2 S |
| 4.02.00 | + MDSTU Multiple Dose Studies | (F) S |
| 4.02.01 | DTYP Data Type | D F S |
| 4.02.03 | SPE Species | D F S |
| 4.02.04 | STU Study | D F S |
| 4.02.05 | DOS Dose | D F S |
| 4.02.06 | EFF Effect | D F S |
| 4.02.07 | RF Reference | D F 2 S |
| 4.03.00 | + MSTU Mutagenicity Study | (F) S |
| 4.03.01 | DTYP Data Type | D F S |
| 4.03.02 | TSY Test System | D F S |
| 4.03.03 | SCR S pecies/Cell Type/Route | S |
| 4.03.04 | DOS Dose | D F S |
| 4.03.06 | RF Reference | D F 2 S |
| 4.04.00 | + CSTU Carcinogenicity Study | (F) S |
| 4.04.01 | DTYP Data Type | D F S |
| 4.04.02 | ROU Route | D F S |
| 4.04.03 | SPE Species | D F S |
| 4.04.04 | STU Study | D F S |
| 4.04.05 | DOS Dose | D F S |
| 4.04.06 | EFF Effect | D F S |
| 4.04.07 | RF Reference | D F 2 S |
| 4.05.00 | + RSTU Reproductive Study | (F) S |
| 4.05.01 | DTYP Data Type | D F S |
| 4.05.02 | ROU Route | D F S |
| 4.05.03 | SPE Species | D F S |
| 4.05.04 | STU Study | D F S |
| 4.05.05 | DOS Dose | D F S |
| 4.05.06 | EFF Effect | D F S |
| 4.05.07 | RF Reference | D F 2 S |
| 4.06.00 | + SSTU Skin and Eye Irritation Study | (F) S |
| 4.06.01 | DTYP Data Type | D F S |
| 4.06.02 | ROU Route | D F S |
| 4.06.03 | SPE Species | D F S |
| 4.06.04 | DOS Dose | D F S |
| 4.06.05 | RF Reference | D F 2 S |
Ausgabe der Suchergebnisse
Mit den Ausgabekommandos: SHOW (S) / MAIL.
Je nach Copyrightbestimmung muss der Parameter USE= DLOAD hinzugefügt werden.
Aus den gefundenen Dokumenten können alle Datenfelder, einzelne Datenfelder oder Gruppen von Datenfeldern angefordert werden. Werden die auszugebenden Felder im Kommando nicht explizit angegeben, so wird in allen Ausgabekommandos die Menge Contents (F= Contents) ausgegeben. Hier werden nur die Daten zur Substanzidentifikation (IDEN) ausgegeben, die restlichen Feldgruppen und werden ohne Feldinhalt angezeigt. Deren Feldinhalte können mit dem Befehl SHOW F= Feldbezeichnung aufgerufen werden.
Feldmengen bei der Ausgabe:
| Kommando | Ausgabe | zugehörige Datenfelder |
|---|---|---|
| F= ALL | alle Datenfelder | Alle Felder der Feldgruppen DAT, IDEN, TOXR, EXSR, TOXI und deren Inhalte |
| F=CONTENTS | DAT, IDEN mit Feldinhalt; die Feldgruppen TOXR, EXSR, TOXI ohne Daten | |
| F=TOXI | CSTU, GSTU, MSTU, MDSTU, RSTU, SSTU |
Suchbeispiel(e)
Mögliche Auswahl der Datenbank in der DIMDI ClassicSearch: SBAS RT00
Thema 1: Substanzsuche
Die Recherche nach Substanzen kann erfolgen über
a) den Deskriptor- Identifier TE (TERMINOLOGY), mit dem die Felder NAME, CR und SYNONYMS abgesucht werden:
FIND TE=PHENOL
b) die CAS- Registry Number (CR)
FIND CR=50-00-0
c) Freitext in den Feldern NAME und SYNONYMS (=TE)
FIND (CHLORO AND NITRO AND PHENOL)/SAME SENT/F=TE
FIND (CHLORO AND NITRO AND PHENOL)/SAME SENT/(NAME;SY)
Thema 2: Konzeptsuche
a) Bei der Recherche nach Sachverhalten werden die entsprechenden Felder oder Feldgruppen - sofern möglich - direkt oder über Freitext (FT) abgesucht. Als Ergebnis erhält man die Substanzen, für die der gewünschte Sachverhalt zutrifft.
Beispiel: Für welche Substanzen ist der LD50-Wert bei oraler Aufnahme beim Hausschwein bekannt?
FIND (SPE=PIG AND ROU =ORAL AND STU =LD50)/SAME CONT
FIND (PIG AND ORAL AND LD50)/GSTU/SAME CONT
Durch Qualifizierung der Suchstichworte mit /SAME CONT(EXT) werden nur die Studien erhalten, die diese Suchbegriffe im KONTEXT enthalten, d. h. in der gleichen Studie.
b) "Selektives SHOW": Wenn man sich bei der SHOW-Ausgabe gezielt nur diejenigen Studien anzeigen möchte, die alle verwendeten Suchbegriffe enthalten, muss man die Suche FIND MEM WHERE < Tabellen- Nr.> anschließen, z.B.:
| Parameter | Suchschritt | Trefferanzahl | Suchformulierung |
|---|---|---|---|
| C= | 1 | 153125 | RT00 |
| S= | 2 | 26 | (ROU=ORAL AND SPE=PIG AND STU=LD50)/SAME CONT |
| 3 | 26 | MEM WHERE 2 | |
In 26 Dokumentationseinheiten werden 27 Einzelstudien mit den Begriffen ORAL, PIG und LD50 gefunden. Das Kommando SHOW F=MEM zeigt in der Ausgabe nur Studien an, die die Suchbedingungen erfüllen:
18/1 von 26 DIMDI: RTECS (RT00) © Portions 2008, U.S. Gov.
| ** DTYP | DATA TYPE | GSTU | GENERAL TOXICITY STUDY 20 of 32 |
| ROU | ROUTE | oral | |
| SPE | SPECIES | pig | |
| STU | STUDY | LD50 | |
| DOS | DOSE | 4 mg/kg | |
| EFF | EFFECT | SENSE ORGANS AND SPECIAL SENSES (NOSE,EYE,EAR, AND TASTE) (Other); GASTROINTESTINAL (Other changes); SKIN AND PPENDAGES (Dermatitis, other) | |
| RF | REFERENCE | Journal of the American Veterinary
Medical Association (American Veterinary Medical Assoc., 930 N.
Meacham Rd., Schaumburg, IL 60196) V.48- 1915-, vol 163, pg 1278, 1973 |
Beispieldokument(e)
2/1 of 1 DIMDI: RTECS (RT00) © Portions 2008, U.S. Gov.
| ++ DAT Datamaintenance | ||
| ND | DOCUMENT NUMBER | RTZI8708000 |
| MD | MACHINE DATE | 20090624 |
| LR | LAST REVISION DATE | 200905 |
| RL | RECORD LENGTH | 19529 |
| ++ IDEN Identification of Substance | ||
| NAME | Zinc sulfate (1:1) | |
| CR | CAS REGISTRY NUMBER | 7733-02-0 |
| WL | WISWESSER LINE NOTATION | ZN S-O4 |
| SY | SYNONYMS | OP-Thal-zin; Optraex; Verazinc; White copperas; White vitriol; Bonazen; Bufopto zinc sulfate; Complexonat; Sulfate de zinc (French); Sulfuric acid, zinc salt (1:1); Zinc sulphate; Zinc vitriol; Zinkosite; Zincomed |
| MF | MOLECULAR FORMULA | O4-S.Zn |
| RTEC | RTECS NUMBER | ZH5260000 |
| MW | MOLECULAR WEIGHT | 161.43 |
| GRC | GROUP OF COMPOUND | Agricultural Chemical; Tumorigen; Drug; Mutagen; Human Data; Primary Irritant; Reproductive Effector |
|
++ TOXR Toxicology and Carcinogenicity
Review + TREV Toxicology Review |
||
| ** TOXICOLOGY REVIEW; FOREAE 7,313,1942; Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.** TOXICOLOGY REVIEW; ENTOX* -,479,2005; Encyclopedia of Toxicology: Reference Book, Elsevier, 2005** TOXICOLOGY REVIEW; HBTME* ,925,2007; Handbook on the Toxicology of Metals (Third Edition) Edited by: Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg and Lars T. Friberg, Elsevier Inc 2007** TOXICOLOGY REVIEW; HUTOX* -,515,1996; Human Toxicology, Edited by: Jacques Descotes, Elsevier B.V., 1996 | ||
| + NEXP NIOSH Exposure Survey | ||
| ** NATIONAL OCCUPATIONAL HAZARD SURVEY 1974: Hazard#:
77220; number of industries: 52; total number of facilities: 3067;
number of occupations: 47; total number of employees: 40653 ** NATIONAL OCCUPATIONAL EXPOSURE SURVEY 1983: Hazard#: 77220; number of industries: 52; total number of facilities: 4755; number of occupations: 66; total number of employees: 89451; total number of female employees: 27887 |
||
|
++ EXSR Exposure Standards and
Regulation + SR Standards and Regulations |
||
| ** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION; FEREAC 54,7740,1989; Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- | ||
| + STA Status of Tests | ||
| ** EPA GENETOX PROGRAM 1988, Negative: Cell
transform.-SA7/SHE; S cerevisiae gene conversion ** EPA TSCA Section 8(b) CHEMICAL INVENTORY ** EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
||
|
++ TOXI Toxicity data + CSTU Carcinogenicity Studies : 1 |
||
| ** DTYP | DATA TYPE | CSTU 1 of 1 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | rabbit |
| STU | STUDY | TDLo |
| DOS | DOSE | 3625 ug/kg/5D-C |
| EFF | EFFECT | TUMORIGENIC (Equivocal tumorigenic agent by RTECS criteria; Tumors at site of application) |
| RF | REFERENCE | Comptes Rendus Hebdomadaires des Seances, Academie des
Sciences. (Paris, France) V.1-261, 1835-1965. For publisher
information, see CRASEV., vol 236, pg 1387, 1953 |
| + GSTU General Toxicity Studies : 24 | ||
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 1 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | human |
| STU | STUDY | TDLo |
| DOS | DOSE | 45 mg/kg/7D-C |
| EFF | EFFECT | CARDIAC (Pulse rate increased without fall in BP); GASTROINTESTINAL (Other changes); BLOOD (Normocytic anemia) |
| RF | REFERENCE | British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-, vol 1, pg 754, 1978 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 2 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | human |
| STU | STUDY | TDLo |
| DOS | DOSE | 106 mg/kg |
| EFF | EFFECT | VASCULAR (BP lowering not characterized in autonomic section); LUNGS,THORAX, OR RESPIRATION (Acute pulmonary edema); GASTROINTESTINAL (Hypermotility, diarrhea) |
| RF | REFERENCE | British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-, vol 1, pg 1390,
1977 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 3 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | man |
| STU | STUDY | TDLo |
| DOS | DOSE | 180 mg/kg/6W-I |
| EFF | EFFECT | BLOOD (Other changes) |
| RF | REFERENCE | JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883-, vol 252, pg 1443, 1984 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 4 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | woman |
| STU | STUDY | TDLo |
| DOS | DOSE | 3120 mg/kg/43W-I |
| EFF | EFFECT | BLOOD (Mycrocytosis with or without anemia; Agranulocytosis); NUTRITIONAL AND GROSS METABOLIC (Changes in other metals) |
| RF | REFERENCE | Gastroenterology. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1943-, vol 94, pg 508, 1988 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 5 of 24 |
| ROU | ROUTE | intraperitoneal |
| SPE | SPECIES | rat |
| STU | STUDY | LD50 |
| DOS | DOSE | 196 mg/kg |
| RF | REFERENCE | Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-, vol 23, pg
153, 1991 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 6 of 24 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | rat |
| STU | STUDY | LDLo |
| DOS | DOSE | 330 mg/kg |
| RF | REFERENCE | Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep. Ger.) V.1-5, 1975-76. Discontinued., vol 1, pg 1, 1975 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 7 of 24 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | rat |
| STU | STUDY | LD50 |
| DOS | DOSE | 69900 ug/kg |
| RF | REFERENCE | Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-, vol 23, pg
153, 1991 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 8 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | mouse |
| STU | STUDY | LD50 |
| DOS | DOSE | 245 mg/kg |
| RF | REFERENCE | Yaoxue Tongbao. Bulletin of Pharmacology. (China International
Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,
1978-88. For publisher information, see ZYZAEU., vol 22, pg 230,
1987 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 9 of 24 |
| ROU | ROUTE | intraperitoneal |
| SPE | SPECIES | mouse |
| STU | STUDY | LD50 |
| DOS | DOSE | 29060 ug/kg |
| RF | REFERENCE | Comptes Rendus Hebdomadaires des Seances, Academie des
Sciences. (Paris, France) V.1-261, 1835-1965. For publisher
information, see CRASEV., vol 256, pg 1043, 1963 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 10 of 24 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | mouse |
| STU | STUDY | LD50 |
| DOS | DOSE | 781 mg/kg |
| EFF | EFFECT | GASTROINTESTINAL (Changes in pancreatic weight); BLOOD (Changes in serum composition); BIOCHEMICAL (Other enzymes) |
| RF | REFERENCE | Japanese Journal of Toxicology and Environmental Health.
(Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan)
V.38- 1992-, vol 44, pg 305, 1998 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 11 of 24 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | mouse |
| STU | STUDY | LD50 |
| DOS | DOSE | 23300 ug/kg |
| RF | REFERENCE | Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas
Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-, vol 23, pg
153, 1991 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 12 of 24 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | dog |
| STU | STUDY | LDLo |
| DOS | DOSE | 78 mg/kg |
| RF | REFERENCE | Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep. Ger.) V.1-5, 1975-76. Discontinued., vol 1, pg 1, 1975 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 13 of 24 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | dog |
| STU | STUDY | LDLo |
| DOS | DOSE | 66 mg/kg |
| RF | REFERENCE | Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep. Ger.) V.1-5, 1975-76. Discontinued., vol 1, pg 1, 1975 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 14 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rabbit |
| STU | STUDY | LD50 |
| DOS | DOSE | 2 gm/kg |
| RF | REFERENCE | International Polymer Science and Technology. (Rapra Technology
Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK), vol 3, pg 93,
1976 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 15 of 24 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | rabbit |
| STU | STUDY | LDLo |
| DOS | DOSE | 300 mg/kg |
| RF | REFERENCE | Environmental Quality and Safety, Supplement. (Stuttgart, Fed.
Rep. Ger.) V.1-5, 1975-76. Discontinued., vol 1, pg 1, 1975 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 16 of 24 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | rabbit |
| STU | STUDY | LDLo |
| DOS | DOSE | 23 mg/kg |
| RF | REFERENCE | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1959-, vol 9, pg 269, 1966 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 17 of 24 |
| ROU | ROUTE | oral |
| SPE | SPECIES | human |
| STU | STUDY | TDLo |
| DOS | DOSE | 14.29 mg/kg |
| EFF | EFFECT | GASTROINTESTINAL (Nausea or vomiting) |
| RF | REFERENCE | Handbook of pesticide toxicology. Robert Krieger ed, Academic
press, 2001, vol 2,1366,2001 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 18 of 24 |
| ROU | ROUTE | intraduodenal |
| SPE | SPECIES | dog |
| STU | STUDY | TDLo |
| DOS | DOSE | 161 mg/kg/1H |
| EFF | EFFECT | GASTROINTESTINAL (Alteration in gastric secretion) |
| RF | REFERENCE | American Journal of Physiology. (American Physiological Soc.,
9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-, vol 248, pg
G28, 1985 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 19 of 24 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | dog |
| STU | STUDY | TDLo |
| DOS | DOSE | 4.8 mg/kg/15M |
| EFF | EFFECT | GASTROINTESTINAL (Alteration in gastric secretion) |
| RF | REFERENCE | American Journal of Physiology. (American Physiological Soc.,
9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-, vol 248, pg
G28, 1985 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 20 of 24 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 33 ug/kg |
| EFF | EFFECT | LUNGS,THORAX, OR RESPIRATION (Sputum); BIOCHEMICAL (Effect on inflammation or mediation of inflammation) |
| RF | REFERENCE | Toxicological Sciences (Oxford University Press, 6277 Sea
Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-, vol 70, pg 73,
2002 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 21 of 24 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 161 ug/kg |
| EFF | EFFECT | CARDIAC (Other changes); LUNGS,THORAX, OR RESPIRATION (Other changes); CARDIAC (Cardiomyopathy including infarction) |
| RF | REFERENCE | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge
Parkway, Akron, OH 44311) V.1- 1981-, vol 78, pg 17, 2004 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 22 of 24 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 131 ug/kg |
| EFF | EFFECT | CARDIAC (Other changes); LUNGS,THORAX, OR RESPIRATION (Acute pulmonary edema); BIOCHEMICAL (Effect on inflammation or mediation of inflammation) |
| RF | REFERENCE | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1959-, vol 211, pg 41, 2006 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 23 of 24 |
| ROU | ROUTE | intraperitoneal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 32.3 gm/kg |
| EFF | EFFECT | LIVER (Other changes); BIOCHEMICAL (Other proteins) |
| RF | REFERENCE | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973-, 213.74.2005 |
| ** DTYP | DATA TYPE | GSTU GENERAL TOXICITY STUDY 24 of 24 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 322.86 ug/kg |
| EFF | EFFECT | CARDIAC (Other changes); NUTRITIONAL AND GROSS METABOLIC (Changes in other metals); BIOCHEMICAL (Multiple enzyme effects) |
| RF | REFERENCE | Journal of Toxicology and Environmental Health, Part A. (Taylor
& Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53-
1998-, vol 69, pg 2011, 2006 |
| + MSTU Mutagenicity Studies : 6 | ||
| ** DTYP | DATA TYPE | MSTU 1 of 6 |
| TSY | TEST SYSTEM | Mutation in Microorganisms |
| SCR | SPECIES/CELL TYPE/ROUTE | Saccharomyces cerevisiae |
| DOS | DOSE | 100 mmol/L (-S9) |
| RF | REFERENCE | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000
AE Amsterdam, Netherlands) V.1- 1964-, vol 117, pg 149, 1983 |
| ** DTYP | DATA TYPE | MSTU 2 of 6 |
| TSY | TEST SYSTEM | Gene Conversion and Mitotic Recombination |
| SCR | SPECIES/CELL TYPE/ROUTE | Saccharomyces cerevisiae |
| DOS | DOSE | 100 mmol/L |
| RF | REFERENCE | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000
AE Amsterdam, Netherlands) V.1- 1964-, vol 117, pg 149, 1983 |
| ** DTYP | DATA TYPE | MSTU 3 of 6 |
| TSY | TEST SYSTEM | DNA Inhibition |
| SCR | SPECIES/CELL TYPE/ROUTE | human-HeLa cell |
| DOS | DOSE | 1 umol/L/4H |
| RF | REFERENCE | Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1966-, vol 32, pg 220, 1984 |
| ** DTYP | DATA TYPE | MSTU 4 of 6 |
| TSY | TEST SYSTEM | Cytogenetic Analysis |
| SCR | SPECIES/CELL TYPE/ROUTE | rat-Ascites tumor |
| DOS | DOSE | 1 gm/kg |
| RF | REFERENCE | Gann. Japanese Journal of Cancer Research. (Tokyo, Japan)
V.1-75, 1907-84. For publisher information, see JJCREP., vol 54, pg
155, 1963 |
| ** DTYP | DATA TYPE | MSTU 5 of 6 |
| TSY | TEST SYSTEM | Micronucleus Test |
| SCR | SPECIES/CELL TYPE/ROUTE | mouse-intraperitoneal |
| DOS | DOSE | 1800 ug/kg |
| RF | REFERENCE | Gongye Weisheng Yu Zhiyebing. Industrial Health and
Occupational Diseases. (China International Book Trading Corp., POB
2820, Beijing, Peop. Rep. China) V.1- 1973-, vol 12, pg 77, 1986 |
| ** DTYP | DATA TYPE | MSTU 6 of 6 |
| TSY | TEST SYSTEM | Morphological Transformation |
| SCR | SPECIES/CELL TYPE/ROUTE | hamster-Embryo |
| DOS | DOSE | 200 umol/L |
| RF | REFERENCE | Cancer Research. (Public Ledger Building, Suit 816, 6th &
Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-, vol 39, pg 193,
1979 |
| + MDSTU Multiple Dose Studies : 14 | ||
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 1 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 74 mg/kg/3D-I |
| EFF | EFFECT | MUSCOLOSKELETAL (Other changes); NUTRITIONAL AND GROSS METABOLIC (Changes in Ca) |
| RF | REFERENCE | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1959-, vol 67, pg 224, 1983 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 2 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 1200 mg/kg/60D-C |
| EFF | EFFECT | LIVER (Other changes); NUTRITIONAL AND GROSS METABOLIC (Changes in other metals) |
| RF | REFERENCE | Zhonghua Yixue Zazhi. Chinese Medical Journal. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1915- Suspended 1967-72., vol 72, pg 391, 1992 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 3 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | mouse |
| STU | STUDY | TDLo |
| DOS | DOSE | 44424 mg/kg/18D-C |
| EFF | EFFECT | GASTROINTESTINAL (Changes in structur or function of exocrine pancreas); BIOCHEMICAL (Other enzymes) |
| RF | REFERENCE | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973-, vol 132, pg 33, 1999 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 4 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | domestic animal |
| STU | STUDY | TDLo |
| DOS | DOSE | 7110 mg/kg/4W-I |
| EFF | EFFECT | GASTROINTESTINAL (Changes in structur or function of exocrine pancreas; Hypermotility, diarrhea); RELATED TO CHRONIC DATA (Death in the "U" date type field) |
| RF | REFERENCE | JAT, Journal of Applied Toxicology. (John Wiley & Sons
Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-,
vol 4, pg 92, 1984 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 5 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 476.7 mg/kg/3W-I |
| EFF | EFFECT | LIVER (Other changes); BIOCHEMICAL (Lipids including transport) |
| RF | REFERENCE | Clinical and Experimental Pharmacology and Physiology.
(Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry
St., Carlton, Vic. 3053, Australia) V.1- 1974-, vol 27, pg 694,
2000 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 6 of 14 |
| ROU | ROUTE | intraperitoneal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 84 mg/kg/4W-I |
| EFF | EFFECT | ENDOCRINE (Evidence of thyroid hyperfunction); BLOOD (Changes in serum composition) |
| RF | REFERENCE | Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973-, vol 195, pg 69, 2004 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 7 of 14 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 267.2 ug/kg/8W-I |
| EFF | EFFECT | CARDIAC (Other changes); LUNGS,THORAX, OR RESPIRATION (Other changes); BIOCHEMICAL (Effect on inflammation or mediation of inflammation) |
| RF | REFERENCE | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge
Parkway, Akron, OH 44311) V.1- 1981-, vol 44, pg 89, 2005 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 8 of 14 |
| ROU | ROUTE | intratracheal |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 267.2 ug/kg/16W-I |
| EFF | EFFECT | CARDIAC (Other changes); LUNGS,THORAX, OR RESPIRATION (Other changes); BIOCHEMICAL (Effect on inflammation or mediation of inflammation) |
| RF | REFERENCE | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge
Parkway, Akron, OH 44311) V.1- 1981-, vol 44, pg 89, 2005 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 9 of 14 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | mouse |
| STU | STUDY | TDLo |
| DOS | DOSE | 40 mg/kg/2D-I |
| EFF | EFFECT | KIDNEY, URETER, BLADDER (Other changes in urine composition; Other changes); BLOOD (Changes in serum composition) |
| RF | REFERENCE | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1
E. First St., Duluth, MN 55802) V.1- 1959-, vol 204, pg 9, 2005 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 10 of 14 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 200 mg/kg/10D-I |
| EFF | EFFECT | LIVER (Other changes) |
| RF | REFERENCE | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000
AE Amsterdam, Netherlands) V.1- 1977-, vol 158, pg 108, 2005 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 11 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | human |
| STU | STUDY | TDLo |
| DOS | DOSE | 560 mg/kg/8W-I |
| EFF | EFFECT | GASTROINTESTINAL (Nausea or vomiting) |
| RF | REFERENCE | British Journal of Dermatology. (Blackwell Scientific Pub.
Ltd., POB 88, Oxford, UK) V.63- 1951-, vol 146, pg 423, 2002 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 12 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 2889 mg/kg/8W-C |
| EFF | EFFECT | LIVER (Other changes); BLOOD (Changes in serum composition); BIOCHEMICAL (Plasma proteins not involving coagulation) |
| RF | REFERENCE | Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave.,
New York, NY 10016) V.1- 1977/78-, vol 1, pg 11, 2006 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 13 of 14 |
| ROU | ROUTE | oral |
| SPE | SPECIES | mouse |
| STU | STUDY | TDLo |
| DOS | DOSE | 36 mg/kg/10D-I |
| EFF | EFFECT | BEHAVIORAL (Food intake); NUTRITIONAL AND GROSS METABOLIC (Other changes); BIOCHEMICAL (Other proteins) |
| RF | REFERENCE | Clinical and Experimental Pharmacology and Physiology.
(Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry
St., Carlton, Vic. 3053, Australia) V.1- 1974-, vol 32, pg 273,
2005 |
| ** DTYP | DATA TYPE | MDSTU MULTIPLE DOSE STUDY 14 of 14 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | mouse |
| STU | STUDY | TDLo |
| DOS | DOSE | 96858 ug/kg/2D-I |
| EFF | EFFECT | CARDIAC (Other changes); BIOCHEMICAL (Cytochrome oxidases) |
| RF | REFERENCE | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000
AE Amsterdam, Netherlands) V.1- 1977-, vol 170, pg 66, 2007 |
| + RSTU Reproductive Studies : 5 | ||
| ** DTYP | DATA TYPE | RSTU REPRODUCTIVE STUDY 1 of 5 |
| ROU | ROUTE | oral |
| SPE | SPECIES | rat |
| STU | STUDY | TDLo |
| DOS | DOSE | 333 mg/kg (1-18D preg) |
| EFF | EFFECT | Effects on Fertility (Post-implantation mortality) |
| RF | REFERENCE | Nutrition Reports International. (Geron-X, Inc., POB 1108, Los
Altos, CA 94022) V.1- 1970-, vol 13, pg 33, 1976 |
| ** DTYP | DATA TYPE | RSTU REPRODUCTIVE STUDY 2 of 5 |
| ROU | ROUTE | intravaginal |
| SPE | SPECIES | rabbit |
| STU | STUDY | TDLo |
| DOS | DOSE | 34573 ug/kg (1D pre) |
| EFF | EFFECT | Effects on Fertility (Female fertility index) |
| RF | REFERENCE | Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022)
V.1- 1970-, vol 22, pg 659, 1980 |
| ** DTYP | DATA TYPE | RSTU REPRODUCTIVE STUDY 3 of 5 |
| ROU | ROUTE | subcutaneous |
| SPE | SPECIES | hamster |
| STU | STUDY | TDLo |
| DOS | DOSE | 15 mg/kg (8D preg) |
| EFF | EFFECT | Effects on Embryo or Fetus (Fetotoxicity); Specific Developmental Abnormalities (Cardiovascular system) |
| RF | REFERENCE | Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967-, vol 35, pg 405, 1984 |
| ** DTYP | DATA TYPE | RSTU REPRODUCTIVE STUDY 4 of 5 |
| ROU | ROUTE | intravenous |
| SPE | SPECIES | hamster |
| STU | STUDY | TDLo |
| DOS | DOSE | 2 mg/kg (8D preg) |
| EFF | EFFECT | Effects on Embryo or Fetus (Fetotoxicity) |
| RF | REFERENCE | Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967-, vol 6, pg 95, 1973 |
| ** DTYP | DATA TYPE | RSTU REPRODUCTIVE STUDY 5 of 5 |
| ROU | ROUTE | oral |
| SPE | SPECIES | domestic animal |
| STU | STUDY | TDLo |
| DOS | DOSE | 193 gm/kg (6-20W preg) |
| EFF | EFFECT | Effects on Fertility (Abortion); Effects on Newborn (Live birth index; Weaning or lactation index) |
| RF | REFERENCE | Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967-, vol 20, pg 1, 1979 |
| + SSTU Skin and Eye Irritation Studies : 1 | ||
| ** DTYP | DATA TYPE | SSTU SKIN AND EYE IRRITATION STUDY 1 of 1 |
| ROU | ROUTE | eye |
| SPE | SPECIES | rabbit |
| DOS | DOSE | 420 ug MOD |
| RF | REFERENCE | Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE., vol 45, pg 474, 1956 |
Ausgabeformat: SHOW F= ALL
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TABLE RTECS ® ABBREVIATIONS
| Abkürzung | Langname |
|---|---|
| asn | - Aspergillus nidulans |
| ast | - Ascites tumo |
| s | - Bacillus subtilis |
| bfa | - body fluid assay |
| bmr | - bone marrow |
| brd | - bird (domestic) |
| bwd | - wild bird species |
| C | - continuous |
| cc | - cubic centimeter |
| chd | - child |
| ckn | - chicken |
| CL | - ceiling concentration |
| clr | - Chlamydomonas reinhardi |
| ctl | - cattle |
| cyt | - cytogenetic analysis |
| D | - day |
| dck | - duck |
| DEF | - definition |
| dlt | - dominant lethal test |
| dmg | - Drosophila melanogaster |
| dnd | - DNA damage |
| dni | - DNA inhibition |
| dnr | - DNA repair |
| dns | - unscheduled DNA synthesis |
| dom | - domestic |
| DOT | - Department of Transportation |
| dpo | - Drosophila pseudo-obscura |
| emb | - embryo |
| EPA | - Environmental Protection Agency |
| esc | - Escherichia coli |
| eug | - Euglena gracillis |
| eye | - administration into the eye (irritant) |
| fb | - fiber |
| fbr | - fibroblast |
| frg | - frog |
| gm | - gram |
| gpg | - guinea pig |
| grb | - gerbil |
| grh | - grasshopper |
| H | - hour |
| ham | - hamster |
| hla | - HeLa cell |
| hma | - host-mediated assay |
| hmi | - Haemophilus influenzae |
| hmn | - human |
| hor | - horse, donkey |
| I | - intermittent |
| ial | - intraaural |
| IARC | - International Agency for Research on Cancer |
| iat | - intraarterial |
| ice | - intracerebral |
| icv | - intravcervical |
| idr | - intradermal |
| idu | - intraduodenal |
| ihl | - inhalation |
| imm | - immersion |
| imp | - implant |
| ims | - intramuscular |
| inf | - infant |
| ipc | - intraplacental |
| ipl | - intrapleural |
| ipr | - intraperitoneal |
| irn | - intrarenal |
| isp | - intraspinal |
| itr | - intratracheal |
| itt | - intratesticular |
| iu | - international unit |
| iut | - intrauterine |
| ivg | - intravaginal |
| ivn | - intravenous |
| kdy | - kidney |
| kg | - kilogram (one thousand grams) |
| klp | - Klebsiella pneumoniae |
| L | - liter |
| LC50 | - lethal concentration, 50 percent kill |
| LCLo | - lowest published lethal concentration |
| LD50 | - lethal dose, 50 percent kill |
| LDLo | - lowest published lethal dose |
| leu | - leukocyte |
| liq | - liquid |
| lng | - lung |
| lvr | - liver |
| lym | - lymphocyte |
| M | - minute |
| m³ | - cubic meter |
| mam | - mammal (species unspecified) |
| mg | - milligram (one thousand of a gram; 10 -3 gram) |
| mky | - monkey |
| mL | - milliliter |
| MLD | - mild irritation effect |
| mma | - microsomal mutagenicity assay |
| mmo | - mutation in microorganisms |
| mmol | - millimole |
| mmr | - mammary gland |
| mnt | - micronucleus test |
| MOD | - moderate irritation effect |
| mol | - mole |
| mppcf | - million particles per cubic foot |
| mrc | - gene conversion and mitotic recombination |
| msc | - mutation in mammalian somatic cells |
| MSHA | - Mine Safety and Health Administration |
| mul | - multiple routes |
| mus | - mouse |
| ng | - nanogram (one billionth of a gram; 10 -9 gram) |
| nml | - non-mammalian species |
| nmol | - nanomole |
| NOES | - National Occupational Exposure Survey |
| NOHS | - National Occupational Hazard Survey |
| nsc | - Neurospora crassa |
| nse | - non-standard exposure |
| NTP | - National Toxicology Program |
| OBS | - obsolete (trade name) |
| ocu | - ocular |
| OEL | - Occupational Exposure Limit |
| ofs | - other fish |
| omi | - other microorganisms |
| oms | - other mutation test systems |
| oin | - other insects |
| open | - open irritation test |
| orl | - oral |
| ORM | - Other Regulated Materials (DOT) |
| OSHA | - Occupational Safety and Health Administration |
| oth | - other cell types |
| otr | - oncogenic transformation |
| ovr | - ovary |
| par | - parental |
| PEL | - Permissible Exposure Limit (OSHA) |
| pg | - picogram (one trillionth of a gram; 10 -12 gram) |
| pgn | - pigeon |
| pic | - phage inhibition capacity |
| pig | - pig |
| PK | - peak concentration |
| pmol | - picomole |
| post | - after birth |
| ppb | - parts per billion (v/v) |
| pph | - parts per hundred (v/v) (percent) |
| ppm | - parts per million (v/v) |
| ppt | - parts per trillion (v/v) |
| pre | - prior to copulation |
| preg | - pregnant |
| qal | - quail |
| rat | - rat |
| rbt | - rabbit |
| rec | - rectal |
| REGS | - standards and regulations |
| REL | - Recommended exposure Level |
| rns | - rinsed with water |
| RTECS ® | - Registry of Toxic Effects of Chemical Substances |
| S | - second |
| sal | - salmon |
| sat | - Salmonella typhimurium |
| sce | - sister chromatid exchange |
| SCP | - Standards Completion Program |
| scu | - subcutaneous |
| SEV | - severe irritation effect |
| skn | - administration onto the skin |
| sln | - sex chromosome loss and nondisjunction |
| slt | - specific locus test |
| slw | - silkworm |
| smc | - Saccharomyes cerevisiae |
| spm | - sperm |
| sql | - squirrel |
| srm | - Serratia marcescens |
| ssp | - Schizosaccharomyes pombe |
| STEL | - short term exposure limit |
| TC | - toxic concentration (other than lowest) |
| TDLo | - lowest published toxic dose |
| tes | - testis |
| TLV | - Threshold Limit Value |
| tod | - toad |
| trk | - turkey |
| trn | - heritable translocation test |
| TWA | - time-weighted average |
| unr | - unreported |
| W | - week |
| wmn | - woman |
| Y | - year |
| % | - percent |
| µg | - microgram (one millionth of a gram; 10 -6 gram) |
| µmol | - micromole |
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